Principal Bioinformatics Scientist I

About the role

Roche's Bioinformatics team builds computational tools for clinical diagnostics to advance precision medicine. As a Principal Bioinformatics Scientist I, you will work at the intersection of computational biology, assay development and software engineering, turning complex genomic data into actionable health insights. You will collaborate with Wet-Lab Assay Development, Software Engineering, CLIA Operations and Quality to design, validate and operationalize next-generation diagnostic tests.

Key responsibilities

• Design, benchmark and optimize scalable, reproducible NGS bioinformatics pipelines using Nextflow, Docker/Singularity and cloud environments.
• Partner with Assay Development and CLIA lab teams to set statistical analysis plans and validate novel diagnostic assays for high sensitivity, specificity and precision.
• Integrate AI coding tools and automated workflows to speed algorithm development, refactoring and data analysis.
• Draft functional and technical specifications to help software engineering teams turn research prototypes into clinical software.
• Implement sample- and run-level statistical QC metrics and maintain QMS-compliant documentation for CAP/CLIA audits.
• Enforce software engineering best practices such as Git version control, continuous integration, unit testing and modular architecture.

Required profile

• Master's degree with 7+ years of related experience, or Ph.D. with 4+ years of related experience (prior or post-grad work counts; post-grad academic lab training will be considered).
• Proven ability to work across multidisciplinary teams including wet-lab scientists, software engineers, lab directors and quality assurance.
• Excellent communication skills in complex, cross-functional environments.

Required skills

• High-throughput sequencing data analysis (targeted panels, WGS/WES, transcriptomics, liquid biopsy/ctDNA)
• Python, R, C++ and Linux/Bash
• Workflow managers (Nextflow) and containerized deployments (Docker/Singularity)
• Use of AI development tools

Relocation benefits are not available. The expected salary range for Mississauga is 115,328 to 151,368, depending on experience and qualifications.